Centredin
Brand names,
Centredin
Analogs
Centredin
Brand Names Mixture
Centredin
Chemical_Formula
C14H19NO2
Centredin
RX_link
http://www.rxlist.com/cgi/generic/methphen.htm
Centredin
fda sheet
Centredin
msds (material safety sheet)
Centredin
Synthesis Reference
M. Hartmann, L. Panizzon, U.S. Pat. 2,507,631 (1950)
Centredin
Molecular Weight
233.306 g/mol
Centredin
Melting Point
224-226oC
Centredin
H2O Solubility
1255mg/L
Centredin
State
Solid
Centredin
LogP
3.192
Centredin
Dosage Forms
Tablets; Tablets (sustained release)
Centredin
Indication
For use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.
Centredin
Pharmacology
Methylphenidate is a central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine.
Centredin
Absorption
Readily absorbed in a biphasic manner. It reaches peak absorption at approximately two hours for the first phase and five hours for the second phase. Bioavailability is low (approximately 30%)
Centredin
side effects and Toxicity
Symptoms of overdose include vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions (may be followed by coma), euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, hyperpyrexia, tachycardia, palpitations, cardiac arrhythmias, hypertension, mydriasis, and dryness of mucous membranes. LD50=190mg/kg (orally in mice)
Centredin
Patient Information
Centredin
Organisms Affected
Humans and other mammals