Methylofenidan
Brand names,
Methylofenidan
Analogs
Methylofenidan
Brand Names Mixture
Methylofenidan
Chemical_Formula
C14H19NO2
Methylofenidan
RX_link
http://www.rxlist.com/cgi/generic/methphen.htm
Methylofenidan
fda sheet
Methylofenidan
msds (material safety sheet)
Methylofenidan
Synthesis Reference
M. Hartmann, L. Panizzon, U.S. Pat. 2,507,631 (1950)
Methylofenidan
Molecular Weight
233.306 g/mol
Methylofenidan
Melting Point
224-226oC
Methylofenidan
H2O Solubility
1255mg/L
Methylofenidan
State
Solid
Methylofenidan
LogP
3.192
Methylofenidan
Dosage Forms
Tablets; Tablets (sustained release)
Methylofenidan
Indication
For use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.
Methylofenidan
Pharmacology
Methylphenidate is a central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine.
Methylofenidan
Absorption
Readily absorbed in a biphasic manner. It reaches peak absorption at approximately two hours for the first phase and five hours for the second phase. Bioavailability is low (approximately 30%)
Methylofenidan
side effects and Toxicity
Symptoms of overdose include vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions (may be followed by coma), euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, hyperpyrexia, tachycardia, palpitations, cardiac arrhythmias, hypertension, mydriasis, and dryness of mucous membranes. LD50=190mg/kg (orally in mice)
Methylofenidan
Patient Information
Methylofenidan
Organisms Affected
Humans and other mammals