Meridil
Brand names,
Meridil
Analogs
Meridil
Brand Names Mixture
Meridil
Chemical_Formula
C14H19NO2
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RX_link
http://www.rxlist.com/cgi/generic/methphen.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
M. Hartmann, L. Panizzon, U.S. Pat. 2,507,631 (1950)
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Molecular Weight
233.306 g/mol
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Melting Point
224-226oC
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H2O Solubility
1255mg/L
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State
Solid
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LogP
3.192
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Dosage Forms
Tablets; Tablets (sustained release)
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Indication
For use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.
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Pharmacology
Methylphenidate is a central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine.
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Absorption
Readily absorbed in a biphasic manner. It reaches peak absorption at approximately two hours for the first phase and five hours for the second phase. Bioavailability is low (approximately 30%)
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side effects and Toxicity
Symptoms of overdose include vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions (may be followed by coma), euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, hyperpyrexia, tachycardia, palpitations, cardiac arrhythmias, hypertension, mydriasis, and dryness of mucous membranes. LD50=190mg/kg (orally in mice)
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Patient Information
Meridil
Organisms Affected
Humans and other mammals