Ritalin LA
Brand names,
Ritalin LA
Analogs
Ritalin LA
Brand Names Mixture
Ritalin LA
Chemical_Formula
C14H19NO2
Ritalin LA
RX_link
http://www.rxlist.com/cgi/generic/methphen.htm
Ritalin LA
fda sheet
Ritalin LA
msds (material safety sheet)
Ritalin LA
Synthesis Reference
M. Hartmann, L. Panizzon, U.S. Pat. 2,507,631 (1950)
Ritalin LA
Molecular Weight
233.306 g/mol
Ritalin LA
Melting Point
224-226oC
Ritalin LA
H2O Solubility
1255mg/L
Ritalin LA
State
Solid
Ritalin LA
LogP
3.192
Ritalin LA
Dosage Forms
Tablets; Tablets (sustained release)
Ritalin LA
Indication
For use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.
Ritalin LA
Pharmacology
Methylphenidate is a central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine.
Ritalin LA
Absorption
Readily absorbed in a biphasic manner. It reaches peak absorption at approximately two hours for the first phase and five hours for the second phase. Bioavailability is low (approximately 30%)
Ritalin LA
side effects and Toxicity
Symptoms of overdose include vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions (may be followed by coma), euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, hyperpyrexia, tachycardia, palpitations, cardiac arrhythmias, hypertension, mydriasis, and dryness of mucous membranes. LD50=190mg/kg (orally in mice)
Ritalin LA
Patient Information
Ritalin LA
Organisms Affected
Humans and other mammals