Centedein
Brand names,
Centedein
Analogs
Centedein
Brand Names Mixture
Centedein
Chemical_Formula
C14H19NO2
Centedein
RX_link
http://www.rxlist.com/cgi/generic/methphen.htm
Centedein
fda sheet
Centedein
msds (material safety sheet)
Centedein
Synthesis Reference
M. Hartmann, L. Panizzon, U.S. Pat. 2,507,631 (1950)
Centedein
Molecular Weight
233.306 g/mol
Centedein
Melting Point
224-226oC
Centedein
H2O Solubility
1255mg/L
Centedein
State
Solid
Centedein
LogP
3.192
Centedein
Dosage Forms
Tablets; Tablets (sustained release)
Centedein
Indication
For use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.
Centedein
Pharmacology
Methylphenidate is a central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine.
Centedein
Absorption
Readily absorbed in a biphasic manner. It reaches peak absorption at approximately two hours for the first phase and five hours for the second phase. Bioavailability is low (approximately 30%)
Centedein
side effects and Toxicity
Symptoms of overdose include vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions (may be followed by coma), euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, hyperpyrexia, tachycardia, palpitations, cardiac arrhythmias, hypertension, mydriasis, and dryness of mucous membranes. LD50=190mg/kg (orally in mice)
Centedein
Patient Information
Centedein
Organisms Affected
Humans and other mammals