Metadate ER
Brand names,
Metadate ER
Analogs
Metadate ER
Brand Names Mixture
Metadate ER
Chemical_Formula
C14H19NO2
Metadate ER
RX_link
http://www.rxlist.com/cgi/generic/methphen.htm
Metadate ER
fda sheet
Metadate ER
msds (material safety sheet)
Metadate ER
Synthesis Reference
M. Hartmann, L. Panizzon, U.S. Pat. 2,507,631 (1950)
Metadate ER
Molecular Weight
233.306 g/mol
Metadate ER
Melting Point
224-226oC
Metadate ER
H2O Solubility
1255mg/L
Metadate ER
State
Solid
Metadate ER
LogP
3.192
Metadate ER
Dosage Forms
Tablets; Tablets (sustained release)
Metadate ER
Indication
For use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.
Metadate ER
Pharmacology
Methylphenidate is a central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine.
Metadate ER
Absorption
Readily absorbed in a biphasic manner. It reaches peak absorption at approximately two hours for the first phase and five hours for the second phase. Bioavailability is low (approximately 30%)
Metadate ER
side effects and Toxicity
Symptoms of overdose include vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions (may be followed by coma), euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, hyperpyrexia, tachycardia, palpitations, cardiac arrhythmias, hypertension, mydriasis, and dryness of mucous membranes. LD50=190mg/kg (orally in mice)
Metadate ER
Patient Information
Metadate ER
Organisms Affected
Humans and other mammals