Orphenadrine en es it fr

Orphenadrine Brand names, Orphenadrine Analogs

Orphenadrine Brand Names Mixture

  • No information avaliable

Orphenadrine Chemical_Formula


Orphenadrine RX_link


Orphenadrine fda sheet

Orphenadrine FDA

Orphenadrine msds (material safety sheet)

Orphenadrine MSDS

Orphenadrine Synthesis Reference

No information avaliable

Orphenadrine Molecular Weight

269.381 g/mol

Orphenadrine Melting Point

156-157 oC

Orphenadrine H2O Solubility

Sparingly soluble in water

Orphenadrine State


Orphenadrine LogP


Orphenadrine Dosage Forms

Tablet (extended-release)

Orphenadrine Indication

Indicated for the treatment of Parkinson's disease.

Orphenadrine Pharmacology

Orphenadrine is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. Orphenadrine is an anticholinergic with a predominantly central effect and only a weak peripheral effect. In addition, it has mild antihistaminic and local anaesthetic properties. Parkinson's syndrome is the consequence of a disturbed balance between cholinergic and dopaminergic neurotransmission in the basal ganglia caused by a decrease in dopamine. Orphenadrine restores the physiological equilibrium and has a favourable effect on the rigidity and tremor of Parkinson's disease and Parkinsonian syndromes. The effect is somewhat less on bradykinesia.

Orphenadrine Absorption

Orphenadrine is almost completely absorbed in the gastrointestinal tract.

Orphenadrine side effects and Toxicity

Oral, mouse LD50 = 100 mg/kg; oral, rat LD50 = 255 mg/kg

Orphenadrine Patient Information

No information avaliable

Orphenadrine Organisms Affected

Humans and other mammals