Orphenate

Orphenate Brand names, Orphenate Analogs

Orphenate Brand Names Mixture

No information avaliable

Orphenate Chemical_Formula

C₁₈H₂₃NO

Orphenate RX_link

http://www.rxlist.com/cgi/generic/orphen.htm

Orphenate fda sheet

Orphenate FDA

Orphenate msds (material safety sheet)

Orphenate MSDS

Orphenate Synthesis Reference

No information avaliable

Orphenate Molecular Weight

269.381 g/mol

Orphenate Melting Point

156-157 ^oC

Orphenate H₂O Solubility

Sparingly soluble in water

Orphenate State

Solid

Orphenate LogP

4.034

Orphenate Dosage Forms

Tablet (extended-release)

Orphenate Indication

Indicated for the treatment of Parkinson's disease.

Orphenate Pharmacology

Orphenadrine is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. Orphenadrine is an anticholinergic with a predominantly central effect and only a weak peripheral effect. In addition, it has mild antihistaminic and local anaesthetic properties. Parkinson's syndrome is the consequence of a disturbed balance between cholinergic and dopaminergic neurotransmission in the basal ganglia caused by a decrease in dopamine. Orphenadrine restores the physiological equilibrium and has a favourable effect on the rigidity and tremor of Parkinson's disease and Parkinsonian syndromes. The effect is somewhat less on bradykinesia.

Orphenate Absorption

Orphenadrine is almost completely absorbed in the gastrointestinal tract.

Orphenate side effects and Toxicity

Oral, mouse LD₅₀ = 100 mg/kg; oral, rat LD₅₀ = 255 mg/kg

Orphenate Patient Information