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Mephenamine Brand names, Mephenamine Analogs

Mephenamine Brand Names Mixture

  • No information avaliable

Mephenamine Chemical_Formula


Mephenamine RX_link

Mephenamine fda sheet

Mephenamine FDA

Mephenamine msds (material safety sheet)

Mephenamine MSDS

Mephenamine Synthesis Reference

No information avaliable

Mephenamine Molecular Weight

269.381 g/mol

Mephenamine Melting Point

156-157 oC

Mephenamine H2O Solubility

Sparingly soluble in water

Mephenamine State


Mephenamine LogP


Mephenamine Dosage Forms

Tablet (extended-release)

Mephenamine Indication

Indicated for the treatment of Parkinson's disease.

Mephenamine Pharmacology

Orphenadrine is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. Orphenadrine is an anticholinergic with a predominantly central effect and only a weak peripheral effect. In addition, it has mild antihistaminic and local anaesthetic properties. Parkinson's syndrome is the consequence of a disturbed balance between cholinergic and dopaminergic neurotransmission in the basal ganglia caused by a decrease in dopamine. Orphenadrine restores the physiological equilibrium and has a favourable effect on the rigidity and tremor of Parkinson's disease and Parkinsonian syndromes. The effect is somewhat less on bradykinesia.

Mephenamine Absorption

Orphenadrine is almost completely absorbed in the gastrointestinal tract.

Mephenamine side effects and Toxicity

Oral, mouse LD50 = 100 mg/kg; oral, rat LD50 = 255 mg/kg

Mephenamine Patient Information

No information avaliable

Mephenamine Organisms Affected

Humans and other mammals