Orphenadine

Orphenadine Brand names, Orphenadine Analogs

Orphenadine Brand Names Mixture

No information avaliable

Orphenadine Chemical_Formula

C₁₈H₂₃NO

Orphenadine RX_link

http://www.rxlist.com/cgi/generic/orphen.htm

Orphenadine fda sheet

Orphenadine FDA

Orphenadine msds (material safety sheet)

Orphenadine MSDS

Orphenadine Synthesis Reference

No information avaliable

Orphenadine Molecular Weight

269.381 g/mol

Orphenadine Melting Point

156-157 ^oC

Orphenadine H₂O Solubility

Sparingly soluble in water

Orphenadine State

Solid

Orphenadine LogP

4.034

Orphenadine Dosage Forms

Tablet (extended-release)

Orphenadine Indication

Indicated for the treatment of Parkinson's disease.

Orphenadine Pharmacology

Orphenadrine is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. Orphenadrine is an anticholinergic with a predominantly central effect and only a weak peripheral effect. In addition, it has mild antihistaminic and local anaesthetic properties. Parkinson's syndrome is the consequence of a disturbed balance between cholinergic and dopaminergic neurotransmission in the basal ganglia caused by a decrease in dopamine. Orphenadrine restores the physiological equilibrium and has a favourable effect on the rigidity and tremor of Parkinson's disease and Parkinsonian syndromes. The effect is somewhat less on bradykinesia.

Orphenadine Absorption

Orphenadrine is almost completely absorbed in the gastrointestinal tract.

Orphenadine side effects and Toxicity

Oral, mouse LD₅₀ = 100 mg/kg; oral, rat LD₅₀ = 255 mg/kg

Orphenadine Patient Information