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Orfro Brand names, Orfro Analogs

Orfro Brand Names Mixture

  • No information avaliable

Orfro Chemical_Formula


Orfro RX_link


Orfro fda sheet

Orfro FDA

Orfro msds (material safety sheet)

Orfro MSDS

Orfro Synthesis Reference

No information avaliable

Orfro Molecular Weight

269.381 g/mol

Orfro Melting Point

156-157 oC

Orfro H2O Solubility

Sparingly soluble in water

Orfro State


Orfro LogP


Orfro Dosage Forms

Tablet (extended-release)

Orfro Indication

Indicated for the treatment of Parkinson's disease.

Orfro Pharmacology

Orphenadrine is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. Orphenadrine is an anticholinergic with a predominantly central effect and only a weak peripheral effect. In addition, it has mild antihistaminic and local anaesthetic properties. Parkinson's syndrome is the consequence of a disturbed balance between cholinergic and dopaminergic neurotransmission in the basal ganglia caused by a decrease in dopamine. Orphenadrine restores the physiological equilibrium and has a favourable effect on the rigidity and tremor of Parkinson's disease and Parkinsonian syndromes. The effect is somewhat less on bradykinesia.

Orfro Absorption

Orphenadrine is almost completely absorbed in the gastrointestinal tract.

Orfro side effects and Toxicity

Oral, mouse LD50 = 100 mg/kg; oral, rat LD50 = 255 mg/kg

Orfro Patient Information

No information avaliable

Orfro Organisms Affected

Humans and other mammals