Myotrol

Myotrol Brand names, Myotrol Analogs

Myotrol Brand Names Mixture

No information avaliable

Myotrol Chemical_Formula

C₁₈H₂₃NO

Myotrol RX_link

http://www.rxlist.com/cgi/generic/orphen.htm

Myotrol fda sheet

Myotrol FDA

Myotrol msds (material safety sheet)

Myotrol MSDS

Myotrol Synthesis Reference

No information avaliable

Myotrol Molecular Weight

269.381 g/mol

Myotrol Melting Point

156-157 ^oC

Myotrol H₂O Solubility

Sparingly soluble in water

Myotrol State

Solid

Myotrol LogP

4.034

Myotrol Dosage Forms

Tablet (extended-release)

Myotrol Indication

Indicated for the treatment of Parkinson's disease.

Myotrol Pharmacology

Orphenadrine is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. Orphenadrine is an anticholinergic with a predominantly central effect and only a weak peripheral effect. In addition, it has mild antihistaminic and local anaesthetic properties. Parkinson's syndrome is the consequence of a disturbed balance between cholinergic and dopaminergic neurotransmission in the basal ganglia caused by a decrease in dopamine. Orphenadrine restores the physiological equilibrium and has a favourable effect on the rigidity and tremor of Parkinson's disease and Parkinsonian syndromes. The effect is somewhat less on bradykinesia.

Myotrol Absorption

Orphenadrine is almost completely absorbed in the gastrointestinal tract.

Myotrol side effects and Toxicity

Oral, mouse LD₅₀ = 100 mg/kg; oral, rat LD₅₀ = 255 mg/kg

Myotrol Patient Information