Orphenedrine en es it fr

Orphenedrine Brand names, Orphenedrine Analogs

Orphenedrine Brand Names Mixture

  • No information avaliable

Orphenedrine Chemical_Formula


Orphenedrine RX_link


Orphenedrine fda sheet

Orphenedrine FDA

Orphenedrine msds (material safety sheet)

Orphenedrine MSDS

Orphenedrine Synthesis Reference

No information avaliable

Orphenedrine Molecular Weight

269.381 g/mol

Orphenedrine Melting Point

156-157 oC

Orphenedrine H2O Solubility

Sparingly soluble in water

Orphenedrine State


Orphenedrine LogP


Orphenedrine Dosage Forms

Tablet (extended-release)

Orphenedrine Indication

Indicated for the treatment of Parkinson's disease.

Orphenedrine Pharmacology

Orphenadrine is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. Orphenadrine is an anticholinergic with a predominantly central effect and only a weak peripheral effect. In addition, it has mild antihistaminic and local anaesthetic properties. Parkinson's syndrome is the consequence of a disturbed balance between cholinergic and dopaminergic neurotransmission in the basal ganglia caused by a decrease in dopamine. Orphenadrine restores the physiological equilibrium and has a favourable effect on the rigidity and tremor of Parkinson's disease and Parkinsonian syndromes. The effect is somewhat less on bradykinesia.

Orphenedrine Absorption

Orphenadrine is almost completely absorbed in the gastrointestinal tract.

Orphenedrine side effects and Toxicity

Oral, mouse LD50 = 100 mg/kg; oral, rat LD50 = 255 mg/kg

Orphenedrine Patient Information

No information avaliable

Orphenedrine Organisms Affected

Humans and other mammals