Antiflex

Antiflex Brand names, Antiflex Analogs

Antiflex Brand Names Mixture

No information avaliable

Antiflex Chemical_Formula

C₁₈H₂₃NO

Antiflex RX_link

http://www.rxlist.com/cgi/generic/orphen.htm

Antiflex fda sheet

Antiflex FDA

Antiflex msds (material safety sheet)

Antiflex MSDS

Antiflex Synthesis Reference

No information avaliable

Antiflex Molecular Weight

269.381 g/mol

Antiflex Melting Point

156-157 ^oC

Antiflex H₂O Solubility

Sparingly soluble in water

Antiflex State

Solid

Antiflex LogP

4.034

Antiflex Dosage Forms

Tablet (extended-release)

Antiflex Indication

Indicated for the treatment of Parkinson's disease.

Antiflex Pharmacology

Orphenadrine is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. Orphenadrine is an anticholinergic with a predominantly central effect and only a weak peripheral effect. In addition, it has mild antihistaminic and local anaesthetic properties. Parkinson's syndrome is the consequence of a disturbed balance between cholinergic and dopaminergic neurotransmission in the basal ganglia caused by a decrease in dopamine. Orphenadrine restores the physiological equilibrium and has a favourable effect on the rigidity and tremor of Parkinson's disease and Parkinsonian syndromes. The effect is somewhat less on bradykinesia.

Antiflex Absorption

Orphenadrine is almost completely absorbed in the gastrointestinal tract.

Antiflex side effects and Toxicity

Oral, mouse LD₅₀ = 100 mg/kg; oral, rat LD₅₀ = 255 mg/kg

Antiflex Patient Information