Orphenadrin

Orphenadrin Brand names, Orphenadrin Analogs

Orphenadrin Brand Names Mixture

No information avaliable

Orphenadrin Chemical_Formula

C₁₈H₂₃NO

Orphenadrin RX_link

http://www.rxlist.com/cgi/generic/orphen.htm

Orphenadrin fda sheet

Orphenadrin FDA

Orphenadrin msds (material safety sheet)

Orphenadrin MSDS

Orphenadrin Synthesis Reference

No information avaliable

Orphenadrin Molecular Weight

269.381 g/mol

Orphenadrin Melting Point

156-157 ^oC

Orphenadrin H₂O Solubility

Sparingly soluble in water

Orphenadrin State

Solid

Orphenadrin LogP

4.034

Orphenadrin Dosage Forms

Tablet (extended-release)

Orphenadrin Indication

Indicated for the treatment of Parkinson's disease.

Orphenadrin Pharmacology

Orphenadrine is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. Orphenadrine is an anticholinergic with a predominantly central effect and only a weak peripheral effect. In addition, it has mild antihistaminic and local anaesthetic properties. Parkinson's syndrome is the consequence of a disturbed balance between cholinergic and dopaminergic neurotransmission in the basal ganglia caused by a decrease in dopamine. Orphenadrine restores the physiological equilibrium and has a favourable effect on the rigidity and tremor of Parkinson's disease and Parkinsonian syndromes. The effect is somewhat less on bradykinesia.

Orphenadrin Absorption

Orphenadrine is almost completely absorbed in the gastrointestinal tract.

Orphenadrin side effects and Toxicity

Oral, mouse LD₅₀ = 100 mg/kg; oral, rat LD₅₀ = 255 mg/kg

Orphenadrin Patient Information