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Disipal Brand names, Disipal Analogs

Disipal Brand Names Mixture

  • No information avaliable

Disipal Chemical_Formula


Disipal RX_link


Disipal fda sheet

Disipal FDA

Disipal msds (material safety sheet)

Disipal MSDS

Disipal Synthesis Reference

No information avaliable

Disipal Molecular Weight

269.381 g/mol

Disipal Melting Point

156-157 oC

Disipal H2O Solubility

Sparingly soluble in water

Disipal State


Disipal LogP


Disipal Dosage Forms

Tablet (extended-release)

Disipal Indication

Indicated for the treatment of Parkinson's disease.

Disipal Pharmacology

Orphenadrine is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. Orphenadrine is an anticholinergic with a predominantly central effect and only a weak peripheral effect. In addition, it has mild antihistaminic and local anaesthetic properties. Parkinson's syndrome is the consequence of a disturbed balance between cholinergic and dopaminergic neurotransmission in the basal ganglia caused by a decrease in dopamine. Orphenadrine restores the physiological equilibrium and has a favourable effect on the rigidity and tremor of Parkinson's disease and Parkinsonian syndromes. The effect is somewhat less on bradykinesia.

Disipal Absorption

Orphenadrine is almost completely absorbed in the gastrointestinal tract.

Disipal side effects and Toxicity

Oral, mouse LD50 = 100 mg/kg; oral, rat LD50 = 255 mg/kg

Disipal Patient Information

No information avaliable

Disipal Organisms Affected

Humans and other mammals