Norflex

Norflex Brand names, Norflex Analogs

Norflex Brand Names Mixture

No information avaliable

Norflex Chemical_Formula

C₁₈H₂₃NO

Norflex RX_link

http://www.rxlist.com/cgi/generic/orphen.htm

Norflex fda sheet

Norflex FDA

Norflex msds (material safety sheet)

Norflex MSDS

Norflex Synthesis Reference

No information avaliable

Norflex Molecular Weight

269.381 g/mol

Norflex Melting Point

156-157 ^oC

Norflex H₂O Solubility

Sparingly soluble in water

Norflex State

Solid

Norflex LogP

4.034

Norflex Dosage Forms

Tablet (extended-release)

Norflex Indication

Indicated for the treatment of Parkinson's disease.

Norflex Pharmacology

Orphenadrine is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. Orphenadrine is an anticholinergic with a predominantly central effect and only a weak peripheral effect. In addition, it has mild antihistaminic and local anaesthetic properties. Parkinson's syndrome is the consequence of a disturbed balance between cholinergic and dopaminergic neurotransmission in the basal ganglia caused by a decrease in dopamine. Orphenadrine restores the physiological equilibrium and has a favourable effect on the rigidity and tremor of Parkinson's disease and Parkinsonian syndromes. The effect is somewhat less on bradykinesia.

Norflex Absorption

Orphenadrine is almost completely absorbed in the gastrointestinal tract.

Norflex side effects and Toxicity

Oral, mouse LD₅₀ = 100 mg/kg; oral, rat LD₅₀ = 255 mg/kg

Norflex Patient Information