Methoxyfluran
Brand names,
Methoxyfluran
Analogs
Methoxyfluran
Brand Names Mixture
Methoxyfluran
Chemical_Formula
C3H4Cl2F2O
Methoxyfluran
RX_link
No information avaliable
Methoxyfluran
fda sheet
Methoxyfluran
msds (material safety sheet)
Methoxyfluran
Synthesis Reference
Miller et al., J. Am. Chem. Soc. 70, 431 (1948)
Methoxyfluran
Molecular Weight
164.965 g/mol
Methoxyfluran
Melting Point
-35 oC (melting point), 105 oC (boiling point)
Methoxyfluran
H2O Solubility
2.83E+004 mg/L
Methoxyfluran
State
Liquid
Methoxyfluran
LogP
2.073
Methoxyfluran
Dosage Forms
Spray
Methoxyfluran
Indication
For use in the induction and maintenance of general anesthesia
Methoxyfluran
Pharmacology
Methoxyflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.
Methoxyfluran
Absorption
No information avaliable
Methoxyfluran
side effects and Toxicity
LD50=3600 mg/kg (Orally in rats). Symptoms of overexposure include eye irritation, CNS depression, analgesia, anesthesia, seizures, respiratory depression, and liver and kidney damage.
Methoxyfluran
Patient Information
No information avaliable
Methoxyfluran
Organisms Affected
Humans and other mammals