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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C3H4Cl2F2O
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Miller et al., J. Am. Chem. Soc. 70, 431 (1948)
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Molecular Weight
164.965 g/mol
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Melting Point
-35 oC (melting point), 105 oC (boiling point)
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H2O Solubility
2.83E+004 mg/L
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State
Liquid
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LogP
2.073
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Dosage Forms
Spray
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Indication
For use in the induction and maintenance of general anesthesia
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Pharmacology
Methoxyflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.
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Absorption
No information avaliable
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side effects and Toxicity
LD50=3600 mg/kg (Orally in rats). Symptoms of overexposure include eye irritation, CNS depression, analgesia, anesthesia, seizures, respiratory depression, and liver and kidney damage.
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals