Mellerette
Brand names,
Mellerette
Analogs
Mellerette
Brand Names Mixture
Mellerette
Chemical_Formula
C21H26N2S2
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RX_link
http://www.rxlist.com/cgi/generic3/thioridazine.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Bourquin et al., Helv. Chim. Acta 41, 1072 (1958)
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Molecular Weight
370.577 g/mol
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Melting Point
73 oC
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H2O Solubility
0.0336 mg/L
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State
Solid
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LogP
6.552
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Dosage Forms
Suspension; Tablet
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Indication
For the treatment of schizophrenia and generalized anxiety disorder.
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Pharmacology
Thioridazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Thioridazine has not been shown effective in the management of behaviorial complications in patients with mental retardation.
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Absorption
60%
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side effects and Toxicity
LD50=956-1034 mg/kg (Orally in rats); Agitation, blurred vision, coma, confusion, constipation, difficulty breathing, dilated or constricted pupils, diminished flow of urine, dry mouth, dry skin, excessively high or low body temperature, extremely low blood pressure, fluid in the lungs, heart abnormalities, inability to urinate, intestinal blockage, nasal congestion, restlessness, sedation, seizures, shock
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Patient Information
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Organisms Affected
Humans and other mammals