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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C12H14N2O2
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RX_link
http://www.rxlist.com/cgi/generic2/primid.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Boon et al., Brit. pat. 666,027 (1952 to I.C.I.)
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Molecular Weight
218.252 g/mol
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Melting Point
281.5 oC
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H2O Solubility
500 mg/L
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State
Solid
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LogP
1.713
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Dosage Forms
Tablet; Chewable tablets; Oral suspension
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Indication
For the treatment of epilepsy
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Pharmacology
Primidone is a barbiturate with anticonvulsant properties. Primidone, either alone or used concomitantly with other anticonvulsants, is indicated in the control of grand mal, psychomotor, and focal epileptic seizures. It may control grand mal seizures refractory to other anticonvulsant therapy. Primidone raises electro- or chemoshock seizure thresholds or alters seizure patterns in experimental animals. Primidone per se has anticonvulsant activity as do its two metabolites, phenobarbital and phenylethylmalonamide (PEMA). In addition to its anticonvulsant activity, Primidone potentiates that of phenobarbital in experimental animals.
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Absorption
90 to 100%
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side effects and Toxicity
No information avaliable
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Patient Information
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Organisms Affected
Humans and other mammals