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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C28H33ClN2
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
433.028 g/mol
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Melting Point
218 oC (BP)
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H2O Solubility
No information avaliable
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State
Liquid
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LogP
7.749
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Dosage Forms
Tablet (50 mg)
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Indication
For prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness and vertigo (dizziness caused by other medical problems).
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Pharmacology
Buclizine is a piperazine-derivative antihistamine used as an antivertigo/antiemetic agent. Buclizine is used in the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness. Additionally, it has been used in the management of vertigo in diseases affecting the vestibular apparatus. Although the mechanism by which buclizine exerts its antiemetic and antivertigo effects has not been fully elucidated, its central anticholinergic properties are partially responsible. The drug depresses labyrinth excitability and vestibular stimulation, and it may affect the medullary chemoreceptor trigger zone. It also possesses anticholinergic, antihistaminic, central nervous system depressant, and local anesthetic effects.
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Absorption
Rapidly absorbed following oral administration.
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side effects and Toxicity
No information avaliable
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Patient Information
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Organisms Affected
Humans and other mammals