Histabutyzine Dihydrochloride
Brand names,
Histabutyzine Dihydrochloride
Analogs
Histabutyzine Dihydrochloride
Brand Names Mixture
Histabutyzine Dihydrochloride
Chemical_Formula
C28H33ClN2
Histabutyzine Dihydrochloride
RX_link
No information avaliable
Histabutyzine Dihydrochloride
fda sheet
Histabutyzine Dihydrochloride
msds (material safety sheet)
Histabutyzine Dihydrochloride
Synthesis Reference
No information avaliable
Histabutyzine Dihydrochloride
Molecular Weight
433.028 g/mol
Histabutyzine Dihydrochloride
Melting Point
218 oC (BP)
Histabutyzine Dihydrochloride
H2O Solubility
No information avaliable
Histabutyzine Dihydrochloride
State
Liquid
Histabutyzine Dihydrochloride
LogP
7.749
Histabutyzine Dihydrochloride
Dosage Forms
Tablet (50 mg)
Histabutyzine Dihydrochloride
Indication
For prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness and vertigo (dizziness caused by other medical problems).
Histabutyzine Dihydrochloride
Pharmacology
Buclizine is a piperazine-derivative antihistamine used as an antivertigo/antiemetic agent. Buclizine is used in the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness. Additionally, it has been used in the management of vertigo in diseases affecting the vestibular apparatus. Although the mechanism by which buclizine exerts its antiemetic and antivertigo effects has not been fully elucidated, its central anticholinergic properties are partially responsible. The drug depresses labyrinth excitability and vestibular stimulation, and it may affect the medullary chemoreceptor trigger zone. It also possesses anticholinergic, antihistaminic, central nervous system depressant, and local anesthetic effects.
Histabutyzine Dihydrochloride
Absorption
Rapidly absorbed following oral administration.
Histabutyzine Dihydrochloride
side effects and Toxicity
No information avaliable
Histabutyzine Dihydrochloride
Patient Information
Histabutyzine Dihydrochloride
Organisms Affected
Humans and other mammals