Histabuticine
Brand names,
Histabuticine
Analogs
Histabuticine
Brand Names Mixture
Histabuticine
Chemical_Formula
C28H33ClN2
Histabuticine
RX_link
No information avaliable
Histabuticine
fda sheet
Histabuticine
msds (material safety sheet)
Histabuticine
Synthesis Reference
No information avaliable
Histabuticine
Molecular Weight
433.028 g/mol
Histabuticine
Melting Point
218 oC (BP)
Histabuticine
H2O Solubility
No information avaliable
Histabuticine
State
Liquid
Histabuticine
LogP
7.749
Histabuticine
Dosage Forms
Tablet (50 mg)
Histabuticine
Indication
For prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness and vertigo (dizziness caused by other medical problems).
Histabuticine
Pharmacology
Buclizine is a piperazine-derivative antihistamine used as an antivertigo/antiemetic agent. Buclizine is used in the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness. Additionally, it has been used in the management of vertigo in diseases affecting the vestibular apparatus. Although the mechanism by which buclizine exerts its antiemetic and antivertigo effects has not been fully elucidated, its central anticholinergic properties are partially responsible. The drug depresses labyrinth excitability and vestibular stimulation, and it may affect the medullary chemoreceptor trigger zone. It also possesses anticholinergic, antihistaminic, central nervous system depressant, and local anesthetic effects.
Histabuticine
Absorption
Rapidly absorbed following oral administration.
Histabuticine
side effects and Toxicity
No information avaliable
Histabuticine
Patient Information
Histabuticine
Organisms Affected
Humans and other mammals