Longifene
Longifene Brand names, Longifene Analogs
- Ancolan
- Ancolon
- Antivert
- Antivert/25
- Antivert/50
- Bonadettes
- Bonadoxin
- Bonamine
- Bonine
- Calmonal
- Chiclida
- Diadril
- Dramamine
- Dramamine II
- Histamethine
- Histamethizine
- Histametizine
- Histametizyne
- Itinerol
- Longifene
- Marex
- Meclicot
- Meclizine Hcl
- Meclozine
- Medivert
- Monamine
- Navicalm
- Neo-Istafene
- Neo-Suprimal
- Neo-Suprimel
- Parachloramine
- Peremesin
- Postafen
- Postafene
- Ravelon
- Sabari
- Sea-Legs
- Siguran
- Subari
- Suprimal
- Travelon
- Veritab
- Vibazine
- Vomisseis
- Vomissels
Longifene Brand Names Mixture
- Antivert Tab (Meclizine Hydrochloride + Nicotinic Acid)
Longifene Chemical_Formula
C25H27ClN2
Longifene RX_link
http://www.rxlist.com/cgi/generic/mecliz.htm
Longifene fda sheet
Longifene msds (material safety sheet)
Longifene Synthesis Reference
Morren, U.S. Pat. 2,709,169 (1955)
Longifene Molecular Weight
390.948 g/mol
Longifene Melting Point
No information avaliable
Longifene H2O Solubility
0.1gm/100ml
Longifene State
Solid
Longifene LogP
5.966
Longifene Dosage Forms
Tablet
Longifene Indication
For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.
Longifene Pharmacology
Meclizine, a piperazine-derivative H1-receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. Meclizine is used in the management of nausea, vomiting, and dizziness associated with motion sickness and vertigo in diseases affecting the vestibular apparatus.
Longifene Absorption
Well absorbed
Longifene side effects and Toxicity
Symptoms of overdose include drowsiness and anticholinergic effects. LD50=mg/kg (orally in rat).
Longifene Patient Information
PATIENT INFORMATION
What are meclizine tablets or capsules?
MECLIZINE (Antivert�, Bonine�) is an antihistamine. It helps to prevent nausea,
vomiting, or dizziness associated with motion sickness, and to treat or prevent
vertigo (extreme dizziness or a sensation that you or your surroundings are
tilting or spinning around). Generic meclizine tablets and capsules are available.
What should my health care professional know before I take meclizine?
They need to know if you have any of these conditions:
- asthma
- glaucoma
- prostate trouble
- stomach problems
- urinary problems
- an unusual or allergic reaction to meclizine, other medicines, foods, dyes,
or preservatives
- breast-feeding
How should I take this medicine?
Take meclizine tablets or capsules by mouth. Follow the directions on the prescription
label. Swallow the tablets or capsules with a drink of water (chewable tablets can be
chewed or swallowed whole). If you are using meclizine to prevent motion sickness, take
the dose at least 1 hour before travel. If meclizine upsets your stomach, take it with
food or milk. Take your doses at regular intervals. Do not take your medicine more often
than directed.
Contact your pediatrician or health care professional regarding the use of this medicine
in children. Special care may be needed.
What if I miss a dose?
If you miss a dose and are taking meclizine on a regular schedule, take it as soon as you
can. If it is almost time for your next dose, take only that dose. Do not take double or
extra doses.
What drug(s) may interact with meclizine?
- alcohol
- barbiturate medicines for inducing sleep or treating seizures (convulsions)
- certain antibiotics given by injection
- digoxin
- medicines for anxiety or sleeping problems, such as alprazolam, diazepam or temazepam
- medicines for hay fever and other allergies
- medicines for mental depression
- medicines for movement abnormalities as in Parkinson's disease, or for gastrointestinal
problems
- medicines for pain
- medicines that relax skeletal muscle
Tell your prescriber or health care professional about all other medicines you are taking,
including non-prescription medicines, nutritional supplements, or herbal products. Also
tell your prescriber or health care professional if you are a frequent user of drinks with
caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way
your medicine works. Check with your health care professional before stopping or starting
any of your medicines.
What side effects may I notice from taking meclizine?
Side effects that you should report to your prescriber or health care professional as soon
as possible:
�fainting spells
�fast or irregular heartbeat (palpitations)
Side effects that usually do not require medical attention (report to your prescriber or
health care professional if they continue or are bothersome):
- blurred vision
- constipation
- difficulty passing urine
- difficulty sleeping
- drowsiness, dizziness
- dry mouth
- headache
- stomach upset
What should I watch for while taking meclizine?
If you are taking meclizine on a regular schedule, visit your prescriber or health care professional
for regular checks on your progress.
You may get dizzy, drowsy or have blurred vision. Do not drive, use machinery, or do anything that
needs mental alertness until you know how meclizine affects you. Do not stand or sit up quickly,
especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol
can increase possible dizziness; avoid alcoholic drinks.
Meclizine may make your mouth dry. Chewing sugarless gum, sucking hard candy and drinking plenty of
water may help. Visit your dentist regularly.
Meclizine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some
discomfort. Lubricating drops may help. See your ophthalmologist if the problem does not go away or
is severe.
Where can I keep my medicine?
Keep out of the reach of children in a container that small children cannot open.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly
closed. Throw away any unused medicine after the expiration date.
What are meclizine tablets or capsules?
MECLIZINE (Antivert�, Bonine�) is an antihistamine. It helps to prevent nausea,
vomiting, or dizziness associated with motion sickness, and to treat or prevent
vertigo (extreme dizziness or a sensation that you or your surroundings are
tilting or spinning around). Generic meclizine tablets and capsules are available.
What should my health care professional know before I take meclizine?
They need to know if you have any of these conditions:
- asthma
- glaucoma
- prostate trouble
- stomach problems
- urinary problems
- an unusual or allergic reaction to meclizine, other medicines, foods, dyes,
or preservatives
- breast-feeding
How should I take this medicine?
Take meclizine tablets or capsules by mouth. Follow the directions on the prescription
label. Swallow the tablets or capsules with a drink of water (chewable tablets can be
chewed or swallowed whole). If you are using meclizine to prevent motion sickness, take
the dose at least 1 hour before travel. If meclizine upsets your stomach, take it with
food or milk. Take your doses at regular intervals. Do not take your medicine more often
than directed.
Contact your pediatrician or health care professional regarding the use of this medicine
in children. Special care may be needed.
What if I miss a dose?
If you miss a dose and are taking meclizine on a regular schedule, take it as soon as you
can. If it is almost time for your next dose, take only that dose. Do not take double or
extra doses.
What drug(s) may interact with meclizine?
- alcohol
- barbiturate medicines for inducing sleep or treating seizures (convulsions)
- certain antibiotics given by injection
- digoxin
- medicines for anxiety or sleeping problems, such as alprazolam, diazepam or temazepam
- medicines for hay fever and other allergies
- medicines for mental depression
- medicines for movement abnormalities as in Parkinson's disease, or for gastrointestinal
problems
- medicines for pain
- medicines that relax skeletal muscle
Tell your prescriber or health care professional about all other medicines you are taking,
including non-prescription medicines, nutritional supplements, or herbal products. Also
tell your prescriber or health care professional if you are a frequent user of drinks with
caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way
your medicine works. Check with your health care professional before stopping or starting
any of your medicines.
What side effects may I notice from taking meclizine?
Side effects that you should report to your prescriber or health care professional as soon
as possible:
�fainting spells
�fast or irregular heartbeat (palpitations)
Side effects that usually do not require medical attention (report to your prescriber or
health care professional if they continue or are bothersome):
- blurred vision
- constipation
- difficulty passing urine
- difficulty sleeping
- drowsiness, dizziness
- dry mouth
- headache
- stomach upset
What should I watch for while taking meclizine?
If you are taking meclizine on a regular schedule, visit your prescriber or health care professional
for regular checks on your progress.
You may get dizzy, drowsy or have blurred vision. Do not drive, use machinery, or do anything that
needs mental alertness until you know how meclizine affects you. Do not stand or sit up quickly,
especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol
can increase possible dizziness; avoid alcoholic drinks.
Meclizine may make your mouth dry. Chewing sugarless gum, sucking hard candy and drinking plenty of
water may help. Visit your dentist regularly.
Meclizine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some
discomfort. Lubricating drops may help. See your ophthalmologist if the problem does not go away or
is severe.
Where can I keep my medicine?
Keep out of the reach of children in a container that small children cannot open.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly
closed. Throw away any unused medicine after the expiration date.
Longifene Organisms Affected
Humans and other mammals
