Bucladin
Brand names,
Bucladin
Analogs
Bucladin
Brand Names Mixture
Bucladin
Chemical_Formula
C28H33ClN2
Bucladin
RX_link
No information avaliable
Bucladin
fda sheet
Bucladin
msds (material safety sheet)
Bucladin
Synthesis Reference
No information avaliable
Bucladin
Molecular Weight
433.028 g/mol
Bucladin
Melting Point
218 oC (BP)
Bucladin
H2O Solubility
No information avaliable
Bucladin
State
Liquid
Bucladin
LogP
7.749
Bucladin
Dosage Forms
Tablet (50 mg)
Bucladin
Indication
For prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness and vertigo (dizziness caused by other medical problems).
Bucladin
Pharmacology
Buclizine is a piperazine-derivative antihistamine used as an antivertigo/antiemetic agent. Buclizine is used in the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness. Additionally, it has been used in the management of vertigo in diseases affecting the vestibular apparatus. Although the mechanism by which buclizine exerts its antiemetic and antivertigo effects has not been fully elucidated, its central anticholinergic properties are partially responsible. The drug depresses labyrinth excitability and vestibular stimulation, and it may affect the medullary chemoreceptor trigger zone. It also possesses anticholinergic, antihistaminic, central nervous system depressant, and local anesthetic effects.
Bucladin
Absorption
Rapidly absorbed following oral administration.
Bucladin
side effects and Toxicity
No information avaliable
Bucladin
Patient Information
Bucladin
Organisms Affected
Humans and other mammals