Histabutyzine
Brand names,
Histabutyzine
Analogs
Histabutyzine
Brand Names Mixture
Histabutyzine
Chemical_Formula
C28H33ClN2
Histabutyzine
RX_link
No information avaliable
Histabutyzine
fda sheet
Histabutyzine
msds (material safety sheet)
Histabutyzine
Synthesis Reference
No information avaliable
Histabutyzine
Molecular Weight
433.028 g/mol
Histabutyzine
Melting Point
218 oC (BP)
Histabutyzine
H2O Solubility
No information avaliable
Histabutyzine
State
Liquid
Histabutyzine
LogP
7.749
Histabutyzine
Dosage Forms
Tablet (50 mg)
Histabutyzine
Indication
For prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness and vertigo (dizziness caused by other medical problems).
Histabutyzine
Pharmacology
Buclizine is a piperazine-derivative antihistamine used as an antivertigo/antiemetic agent. Buclizine is used in the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness. Additionally, it has been used in the management of vertigo in diseases affecting the vestibular apparatus. Although the mechanism by which buclizine exerts its antiemetic and antivertigo effects has not been fully elucidated, its central anticholinergic properties are partially responsible. The drug depresses labyrinth excitability and vestibular stimulation, and it may affect the medullary chemoreceptor trigger zone. It also possesses anticholinergic, antihistaminic, central nervous system depressant, and local anesthetic effects.
Histabutyzine
Absorption
Rapidly absorbed following oral administration.
Histabutyzine
side effects and Toxicity
No information avaliable
Histabutyzine
Patient Information
Histabutyzine
Organisms Affected
Humans and other mammals