Buclina
Brand names,
Buclina
Analogs
Buclina
Brand Names Mixture
Buclina
Chemical_Formula
C28H33ClN2
Buclina
RX_link
No information avaliable
Buclina
fda sheet
Buclina
msds (material safety sheet)
Buclina
Synthesis Reference
No information avaliable
Buclina
Molecular Weight
433.028 g/mol
Buclina
Melting Point
218 oC (BP)
Buclina
H2O Solubility
No information avaliable
Buclina
State
Liquid
Buclina
LogP
7.749
Buclina
Dosage Forms
Tablet (50 mg)
Buclina
Indication
For prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness and vertigo (dizziness caused by other medical problems).
Buclina
Pharmacology
Buclizine is a piperazine-derivative antihistamine used as an antivertigo/antiemetic agent. Buclizine is used in the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness. Additionally, it has been used in the management of vertigo in diseases affecting the vestibular apparatus. Although the mechanism by which buclizine exerts its antiemetic and antivertigo effects has not been fully elucidated, its central anticholinergic properties are partially responsible. The drug depresses labyrinth excitability and vestibular stimulation, and it may affect the medullary chemoreceptor trigger zone. It also possesses anticholinergic, antihistaminic, central nervous system depressant, and local anesthetic effects.
Buclina
Absorption
Rapidly absorbed following oral administration.
Buclina
side effects and Toxicity
No information avaliable
Buclina
Patient Information
Buclina
Organisms Affected
Humans and other mammals