Azelaic Acid
Azelaic Acid Brand names, Azelaic Acid Analogs
Azelaic Acid Brand Names Mixture
- No information avaliable
Azelaic Acid Chemical_Formula
C9H16O4
Azelaic Acid RX_link
http://www.rxlist.com/cgi/generic3/azelex.htm
Azelaic Acid fda sheet
Azelaic Acid msds (material safety sheet)
Azelaic Acid Synthesis Reference
No information avaliable
Azelaic Acid Molecular Weight
188.221 g/mol
Azelaic Acid Melting Point
106.5 oC
Azelaic Acid H2O Solubility
2400 mg/L (20°C)
Azelaic Acid State
Solid
Azelaic Acid LogP
1.646
Azelaic Acid Dosage Forms
Cream (20%)
Azelaic Acid Indication
For the topical treatment of mild-to-moderate inflammatory acne vulgaris.
Azelaic Acid Pharmacology
Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. It is a natural substance that is produced by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin. It is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%. It works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear. Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
Azelaic Acid Absorption
Approximately 4% of the topically applied azelaic acid is systemically absorbed.
Azelaic Acid side effects and Toxicity
Oral, rat: LD50 = >5 gm/kg.
Azelaic Acid Patient Information
Azelaic Acid Organisms Affected
Various aerobic and anaerobic microorganisms
