Lepargylic acid
Lepargylic acid Brand names, Lepargylic acid Analogs
Lepargylic acid Brand Names Mixture
- No information avaliable
Lepargylic acid Chemical_Formula
C9H16O4
Lepargylic acid RX_link
http://www.rxlist.com/cgi/generic3/azelex.htm
Lepargylic acid fda sheet
Lepargylic acid msds (material safety sheet)
Lepargylic acid Synthesis Reference
No information avaliable
Lepargylic acid Molecular Weight
188.221 g/mol
Lepargylic acid Melting Point
106.5 oC
Lepargylic acid H2O Solubility
2400 mg/L (20°C)
Lepargylic acid State
Solid
Lepargylic acid LogP
1.646
Lepargylic acid Dosage Forms
Cream (20%)
Lepargylic acid Indication
For the topical treatment of mild-to-moderate inflammatory acne vulgaris.
Lepargylic acid Pharmacology
Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. It is a natural substance that is produced by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin. It is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%. It works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear. Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
Lepargylic acid Absorption
Approximately 4% of the topically applied azelaic acid is systemically absorbed.
Lepargylic acid side effects and Toxicity
Oral, rat: LD50 = >5 gm/kg.
Lepargylic acid Patient Information
Lepargylic acid Organisms Affected
Various aerobic and anaerobic microorganisms
