Nonanedioic acid
Nonanedioic acid Brand names, Nonanedioic acid Analogs
Nonanedioic acid Brand Names Mixture
- No information avaliable
Nonanedioic acid Chemical_Formula
C9H16O4
Nonanedioic acid RX_link
http://www.rxlist.com/cgi/generic3/azelex.htm
Nonanedioic acid fda sheet
Nonanedioic acid msds (material safety sheet)
Nonanedioic acid Synthesis Reference
No information avaliable
Nonanedioic acid Molecular Weight
188.221 g/mol
Nonanedioic acid Melting Point
106.5 oC
Nonanedioic acid H2O Solubility
2400 mg/L (20°C)
Nonanedioic acid State
Solid
Nonanedioic acid LogP
1.646
Nonanedioic acid Dosage Forms
Cream (20%)
Nonanedioic acid Indication
For the topical treatment of mild-to-moderate inflammatory acne vulgaris.
Nonanedioic acid Pharmacology
Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. It is a natural substance that is produced by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin. It is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%. It works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear. Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
Nonanedioic acid Absorption
Approximately 4% of the topically applied azelaic acid is systemically absorbed.
Nonanedioic acid side effects and Toxicity
Oral, rat: LD50 = >5 gm/kg.
Nonanedioic acid Patient Information
Nonanedioic acid Organisms Affected
Various aerobic and anaerobic microorganisms
