Skinoren
Skinoren Brand names, Skinoren Analogs
Skinoren Brand Names Mixture
- No information avaliable
Skinoren Chemical_Formula
C9H16O4
Skinoren RX_link
http://www.rxlist.com/cgi/generic3/azelex.htm
Skinoren fda sheet
Skinoren msds (material safety sheet)
Skinoren Synthesis Reference
No information avaliable
Skinoren Molecular Weight
188.221 g/mol
Skinoren Melting Point
106.5 oC
Skinoren H2O Solubility
2400 mg/L (20°C)
Skinoren State
Solid
Skinoren LogP
1.646
Skinoren Dosage Forms
Cream (20%)
Skinoren Indication
For the topical treatment of mild-to-moderate inflammatory acne vulgaris.
Skinoren Pharmacology
Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. It is a natural substance that is produced by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin. It is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%. It works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear. Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
Skinoren Absorption
Approximately 4% of the topically applied azelaic acid is systemically absorbed.
Skinoren side effects and Toxicity
Oral, rat: LD50 = >5 gm/kg.
Skinoren Patient Information
Skinoren Organisms Affected
Various aerobic and anaerobic microorganisms
