Azelex
Azelex Brand names, Azelex Analogs
Azelex Brand Names Mixture
- No information avaliable
Azelex Chemical_Formula
C9H16O4
Azelex RX_link
http://www.rxlist.com/cgi/generic3/azelex.htm
Azelex fda sheet
Azelex msds (material safety sheet)
Azelex Synthesis Reference
No information avaliable
Azelex Molecular Weight
188.221 g/mol
Azelex Melting Point
106.5 oC
Azelex H2O Solubility
2400 mg/L (20°C)
Azelex State
Solid
Azelex LogP
1.646
Azelex Dosage Forms
Cream (20%)
Azelex Indication
For the topical treatment of mild-to-moderate inflammatory acne vulgaris.
Azelex Pharmacology
Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. It is a natural substance that is produced by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin. It is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%. It works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear. Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
Azelex Absorption
Approximately 4% of the topically applied azelaic acid is systemically absorbed.
Azelex side effects and Toxicity
Oral, rat: LD50 = >5 gm/kg.
Azelex Patient Information
Azelex Organisms Affected
Various aerobic and anaerobic microorganisms
