Emerox 1110
Brand names,
Emerox 1110
Analogs
Emerox 1110
Brand Names Mixture
Emerox 1110
Chemical_Formula
C9H16O4
Emerox 1110
RX_link
http://www.rxlist.com/cgi/generic3/azelex.htm
Emerox 1110
fda sheet
Emerox 1110
msds (material safety sheet)
Emerox 1110
Synthesis Reference
No information avaliable
Emerox 1110
Molecular Weight
188.221 g/mol
Emerox 1110
Melting Point
106.5 oC
Emerox 1110
H2O Solubility
2400 mg/L (20°C)
Emerox 1110
State
Solid
Emerox 1110
LogP
1.646
Emerox 1110
Dosage Forms
Cream (20%)
Emerox 1110
Indication
For the topical treatment of mild-to-moderate inflammatory acne vulgaris.
Emerox 1110
Pharmacology
Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. It is a natural substance that is produced by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin. It is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%. It works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear. Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
Emerox 1110
Absorption
Approximately 4% of the topically applied azelaic acid is systemically absorbed.
Emerox 1110
side effects and Toxicity
Oral, rat: LD50 = >5 gm/kg.
Emerox 1110
Patient Information
Emerox 1110
Organisms Affected
Various aerobic and anaerobic microorganisms