Azalaic Acid
Azalaic Acid Brand names, Azalaic Acid Analogs
Azalaic Acid Brand Names Mixture
- No information avaliable
Azalaic Acid Chemical_Formula
C9H16O4
Azalaic Acid RX_link
http://www.rxlist.com/cgi/generic3/azelex.htm
Azalaic Acid fda sheet
Azalaic Acid msds (material safety sheet)
Azalaic Acid Synthesis Reference
No information avaliable
Azalaic Acid Molecular Weight
188.221 g/mol
Azalaic Acid Melting Point
106.5 oC
Azalaic Acid H2O Solubility
2400 mg/L (20°C)
Azalaic Acid State
Solid
Azalaic Acid LogP
1.646
Azalaic Acid Dosage Forms
Cream (20%)
Azalaic Acid Indication
For the topical treatment of mild-to-moderate inflammatory acne vulgaris.
Azalaic Acid Pharmacology
Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. It is a natural substance that is produced by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin. It is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%. It works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear. Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
Azalaic Acid Absorption
Approximately 4% of the topically applied azelaic acid is systemically absorbed.
Azalaic Acid side effects and Toxicity
Oral, rat: LD50 = >5 gm/kg.
Azalaic Acid Patient Information
Azalaic Acid Organisms Affected
Various aerobic and anaerobic microorganisms
