Categorie
Coobalamed
Les marques,
Coobalamed
Analogs
Coobalamed
Les marques melange
Liver-Stomach Concentrate with Intrinsic Factor (Special Liver-Stomach Concentrate + Vitamin B 12 + Iron + Ascorbic Acid + Folic Acid)
Coobalamed
Formule chimique
C63H88CoN14O14P
Coobalamed
RX lien
http://www.rxlist.com/cgi/generic2/hminfr.htm
Coobalamed
FDA fiche
Coobalamed
msds (fiche de securite des materiaux)
Coobalamed
Synthese de reference
Aucune information disponible
Coobalamed
Poids moleculaire
1355.37 g/mol
Coobalamed
Point de fusion
> 300 oC
Coobalamed
H2O Solubilite
1.25E 004 mg / L
Coobalamed
Etat
Solid
Coobalamed
LogP
3.57
Coobalamed
Formes pharmaceutiques
Intra-nasale de gel; parentérale (voie orale)
Coobalamed
Indication
Pour le traitement de l'anémie pernicieuse (en raison de l'absence ou l'inhibition du facteur intrinsèque) et pour la prévention et le traitement de vitamine B 12.
Coobalamed
Pharmacologie
La vitamine B12 est un composé soluble dans l'eau organométallique avec un ion cobalt trivalent liés intérieur d'un anneau corrine. Il isneeded pour les cellules nerveuses et des globules rouges, et de faire de l'ADN. Carence en vitamine B12 est la cause de plusieurs formes d'anémie.
Coobalamed
Absorption
Facilement absorbé dans la moitié inférieure de l'iléon.
Coobalamed
Toxicite
Réaction anaphylactique (éruption cutanée, des démangeaisons, une respiration sifflante)-après administration parentérale. BDL-MUS LD50> 8000 mg / kg
Coobalamed
Information pour les patients
Patients with pernicious anemia should be informed that they will require monthly injections of vitamin B12 for the remainder of their lives. Failure to do so will result in return of the anemia and in development of incapacitating and irreversible damage to the nerves of the spinal cord. Also, patients should be warned about the danger of taking folic acid in place of vitamin B12, because the former may prevent anemia but allow progression of subacute combined degeneration. A vegetarian diet which contains no animal products (including milk products or eggs) does not supply any vitamin B12. Patients following such a diet, should be advised to take oral vitamin B12 regularly. The need for vitamin B12 is increased by pregnancy and lactation. Deficiency has been recognized in infants of vegetarian mothers who were breast fed, even though the mothers had no symptoms of deficiency at the time.
Coobalamed
Organismes affectes
Les humains et autres mammifères