Categoria
Vitamin B12b
Nombres de marca,
Vitamin B12b
Analogos
Vitamin B12b
Marca los nombres de mezcla
Liver-Stomach Concentrate with Intrinsic Factor (Special Liver-Stomach Concentrate + Vitamin B 12 + Iron + Ascorbic Acid + Folic Acid)
Vitamin B12b
Formula quimica
C63H88CoN14O14P
Vitamin B12b
RX enlace
http://www.rxlist.com/cgi/generic2/hminfr.htm
Vitamin B12b
FDA hoja
Vitamin B12b
MSDS (hoja de seguridad de materiales)
Vitamin B12b
Sintesis de referencia
No hay información disponible
Vitamin B12b
Peso molecular
1355.37 g/mol
Vitamin B12b
Punto de fusion
> 300 oC
Vitamin B12b
H2O Solubilidad
1.25E 004 mg / L
Vitamin B12b
Estado
Solid
Vitamin B12b
LogP
3.57
Vitamin B12b
Formas de dosificacion
Intranasal gel; parenteral (oral)
Vitamin B12b
Indicacion
Para el tratamiento de la anemia perniciosa (debida a la falta o la inhibición del factor intrínseco) y para la prevención y tratamiento de la deficiencia de vitamina B12.
Vitamin B12b
Farmacologia
La vitamina B12 es un compuesto organometálico soluble en agua con un ion cobalto trivalente atado dentro de un anillo de corrina. Se isneeded para las células nerviosas y los glóbulos rojos, y para hacer el ADN. Deficiencia de vitamina B12 es la causa de varias formas de anemia.
Vitamin B12b
Absorcion
Se absorbe rápidamente en la mitad inferior del íleon.
Vitamin B12b
Toxicidad
Reacción anafiláctica (erupciones en la piel, picazón, dificultad para respirar) después de la administración parenteral. ORL-MUS LD50> 8000 mg / kg
Vitamin B12b
Informacion de Pacientes
Patients with pernicious anemia should be informed that they will require monthly injections of vitamin B12 for the remainder of their lives. Failure to do so will result in return of the anemia and in development of incapacitating and irreversible damage to the nerves of the spinal cord. Also, patients should be warned about the danger of taking folic acid in place of vitamin B12, because the former may prevent anemia but allow progression of subacute combined degeneration. A vegetarian diet which contains no animal products (including milk products or eggs) does not supply any vitamin B12. Patients following such a diet, should be advised to take oral vitamin B12 regularly. The need for vitamin B12 is increased by pregnancy and lactation. Deficiency has been recognized in infants of vegetarian mothers who were breast fed, even though the mothers had no symptoms of deficiency at the time.
Vitamin B12b
Organismos afectados
Humanos y otros mamíferos