Categoria
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Nombres de marca,
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Analogos
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Marca los nombres de mezcla
Liver-Stomach Concentrate with Intrinsic Factor (Special Liver-Stomach Concentrate + Vitamin B 12 + Iron + Ascorbic Acid + Folic Acid)
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Formula quimica
C63H88CoN14O14P
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RX enlace
http://www.rxlist.com/cgi/generic2/hminfr.htm
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FDA hoja
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MSDS (hoja de seguridad de materiales)
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Sintesis de referencia
No hay información disponible
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Peso molecular
1355.37 g/mol
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Punto de fusion
> 300 oC
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H2O Solubilidad
1.25E 004 mg / L
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Estado
Solid
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LogP
3.57
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Formas de dosificacion
Intranasal gel; parenteral (oral)
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Indicacion
Para el tratamiento de la anemia perniciosa (debida a la falta o la inhibición del factor intrínseco) y para la prevención y tratamiento de la deficiencia de vitamina B12.
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Farmacologia
La vitamina B12 es un compuesto organometálico soluble en agua con un ion cobalto trivalente atado dentro de un anillo de corrina. Se isneeded para las células nerviosas y los glóbulos rojos, y para hacer el ADN. Deficiencia de vitamina B12 es la causa de varias formas de anemia.
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Absorcion
Se absorbe rápidamente en la mitad inferior del íleon.
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Toxicidad
Reacción anafiláctica (erupciones en la piel, picazón, dificultad para respirar) después de la administración parenteral. ORL-MUS LD50> 8000 mg / kg
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Informacion de Pacientes
Patients with pernicious anemia should be informed that they will require monthly injections of vitamin B12 for the remainder of their lives. Failure to do so will result in return of the anemia and in development of incapacitating and irreversible damage to the nerves of the spinal cord. Also, patients should be warned about the danger of taking folic acid in place of vitamin B12, because the former may prevent anemia but allow progression of subacute combined degeneration. A vegetarian diet which contains no animal products (including milk products or eggs) does not supply any vitamin B12. Patients following such a diet, should be advised to take oral vitamin B12 regularly. The need for vitamin B12 is increased by pregnancy and lactation. Deficiency has been recognized in infants of vegetarian mothers who were breast fed, even though the mothers had no symptoms of deficiency at the time.
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Organismos afectados
Humanos y otros mamíferos