Tretinoin

Tretinoin Brand names, Tretinoin Analogs

Tretinoin Brand Names Mixture

No information avaliable

Tretinoin Chemical_Formula

C₂₀H₂₈O₂

Tretinoin RX_link

http://www.rxlist.com/cgi/generic/tretinoin.htm

Tretinoin fda sheet

Tretinoin FDA

Tretinoin msds (material safety sheet)

Tretinoin MSDS

Tretinoin Synthesis Reference

Matsui et al.; J.Vitaminol.; 4; 190, 192(1958)

Tretinoin Molecular Weight

300.435 g/mol

Tretinoin Melting Point

181 ^oC

Tretinoin H₂O Solubility

<0.1 g/100 mL

Tretinoin State

Solid

Tretinoin LogP

5.067

Tretinoin Dosage Forms

Capsule; Cream; Gel; Liquid

Tretinoin Indication

For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.

Tretinoin Pharmacology

Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).

Tretinoin Absorption

1-31% (topical);

Tretinoin side effects and Toxicity

No information avaliable

Tretinoin Patient Information