Aknoten

Aknoten Brand names, Aknoten Analogs

Aknoten Brand Names Mixture

No information avaliable

Aknoten Chemical_Formula

C₂₀H₂₈O₂

Aknoten RX_link

http://www.rxlist.com/cgi/generic/tretinoin.htm

Aknoten fda sheet

Aknoten FDA

Aknoten msds (material safety sheet)

Aknoten MSDS

Aknoten Synthesis Reference

Matsui et al.; J.Vitaminol.; 4; 190, 192(1958)

Aknoten Molecular Weight

300.435 g/mol

Aknoten Melting Point

181 ^oC

Aknoten H₂O Solubility

<0.1 g/100 mL

Aknoten State

Solid

Aknoten LogP

5.067

Aknoten Dosage Forms

Capsule; Cream; Gel; Liquid

Aknoten Indication

For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.

Aknoten Pharmacology

Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).

Aknoten Absorption

1-31% (topical);

Aknoten side effects and Toxicity

No information avaliable

Aknoten Patient Information