Lsotretinoin

Lsotretinoin Brand names, Lsotretinoin Analogs

Lsotretinoin Brand Names Mixture

No information avaliable

Lsotretinoin Chemical_Formula

C₂₀H₂₈O₂

Lsotretinoin RX_link

http://www.rxlist.com/cgi/generic/tretinoin.htm

Lsotretinoin fda sheet

Lsotretinoin FDA

Lsotretinoin msds (material safety sheet)

Lsotretinoin MSDS

Lsotretinoin Synthesis Reference

Matsui et al.; J.Vitaminol.; 4; 190, 192(1958)

Lsotretinoin Molecular Weight

300.435 g/mol

Lsotretinoin Melting Point

181 ^oC

Lsotretinoin H₂O Solubility

<0.1 g/100 mL

Lsotretinoin State

Solid

Lsotretinoin LogP

5.067

Lsotretinoin Dosage Forms

Capsule; Cream; Gel; Liquid

Lsotretinoin Indication

For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.

Lsotretinoin Pharmacology

Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).

Lsotretinoin Absorption

1-31% (topical);

Lsotretinoin side effects and Toxicity

No information avaliable

Lsotretinoin Patient Information