Airol
Brand names,
Airol
Analogs
Airol
Brand Names Mixture
Airol
Chemical_Formula
C20H28O2
Airol
RX_link
http://www.rxlist.com/cgi/generic/tretinoin.htm
Airol
fda sheet
Airol
msds (material safety sheet)
Airol
Synthesis Reference
Matsui et al.; J.Vitaminol.; 4; 190, 192(1958)
Airol
Molecular Weight
300.435 g/mol
Airol
Melting Point
181 oC
Airol
H2O Solubility
<0.1 g/100 mL
Airol
State
Solid
Airol
LogP
5.067
Airol
Dosage Forms
Capsule; Cream; Gel; Liquid
Airol
Indication
For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.
Airol
Pharmacology
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).
Airol
Absorption
1-31% (topical);
Airol
side effects and Toxicity
No information avaliable
Airol
Patient Information
No information avaliable
Airol
Organisms Affected
Humans and other mammals