Tri-Luma
Brand names,
Tri-Luma
Analogs
Tri-Luma
Brand Names Mixture
Tri-Luma
Chemical_Formula
C20H28O2
Tri-Luma
RX_link
http://www.rxlist.com/cgi/generic/tretinoin.htm
Tri-Luma
fda sheet
Tri-Luma
msds (material safety sheet)
Tri-Luma
Synthesis Reference
Matsui et al.; J.Vitaminol.; 4; 190, 192(1958)
Tri-Luma
Molecular Weight
300.435 g/mol
Tri-Luma
Melting Point
181 oC
Tri-Luma
H2O Solubility
<0.1 g/100 mL
Tri-Luma
State
Solid
Tri-Luma
LogP
5.067
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Dosage Forms
Capsule; Cream; Gel; Liquid
Tri-Luma
Indication
For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.
Tri-Luma
Pharmacology
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).
Tri-Luma
Absorption
1-31% (topical);
Tri-Luma
side effects and Toxicity
No information avaliable
Tri-Luma
Patient Information
No information avaliable
Tri-Luma
Organisms Affected
Humans and other mammals