Dermairol
Brand names,
Dermairol
Analogs
Dermairol
Brand Names Mixture
Dermairol
Chemical_Formula
C20H28O2
Dermairol
RX_link
http://www.rxlist.com/cgi/generic/tretinoin.htm
Dermairol
fda sheet
Dermairol
msds (material safety sheet)
Dermairol
Synthesis Reference
Matsui et al.; J.Vitaminol.; 4; 190, 192(1958)
Dermairol
Molecular Weight
300.435 g/mol
Dermairol
Melting Point
181 oC
Dermairol
H2O Solubility
<0.1 g/100 mL
Dermairol
State
Solid
Dermairol
LogP
5.067
Dermairol
Dosage Forms
Capsule; Cream; Gel; Liquid
Dermairol
Indication
For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.
Dermairol
Pharmacology
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).
Dermairol
Absorption
1-31% (topical);
Dermairol
side effects and Toxicity
No information avaliable
Dermairol
Patient Information
No information avaliable
Dermairol
Organisms Affected
Humans and other mammals