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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C20H28O2
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RX_link
http://www.rxlist.com/cgi/generic/tretinoin.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Matsui et al.; J.Vitaminol.; 4; 190, 192(1958)
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Molecular Weight
300.435 g/mol
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Melting Point
181 oC
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H2O Solubility
<0.1 g/100 mL
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State
Solid
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LogP
5.067
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Dosage Forms
Capsule; Cream; Gel; Liquid
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Indication
For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.
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Pharmacology
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).
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Absorption
1-31% (topical);
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side effects and Toxicity
No information avaliable
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals