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Tetracyn Brand names, Tetracyn Analogs

Tetracyn Brand Names Mixture

  • Delta-Albaplex tablets (Novobiocin sodium + Prednisolone + Tetracycline hydrochloride)
  • Neo Chlor PWR (Neomycin sulfate + Tetracycline hydrochloride)
  • Neo-Chlor (Neomycin sulfate + Tetracycline hydrochloride)
  • Neotetramed PWR (Neomycin sulfate + Tetracycline hydrochloride)
  • P Onytricin P (Calcium D-pantothenate + Menadione sodium bisulfite + Nicotinamide + Tetracycline hydrochloride + Vitamin A + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin D3 + Vitamin E)

Tetracyn Chemical_Formula

C22H24N2O8

Tetracyn RX_link

http://www.rxlist.com/cgi/generic2/tetcycl2.htm

Tetracyn fda sheet

Tetracyn msds (material safety sheet)

Tetracyn MSDS

Tetracyn Synthesis Reference

J. H. Boothe et al., J. Am. Chem. Soc. 75, 4621 (1953)

Tetracyn Molecular Weight

444.435 g/mol

Tetracyn Melting Point

165oC

Tetracyn H2O Solubility

231 mg/L at 25 oC (SRC PhysProp experimental -- YALKOWSKY,SH & DANNENFELSER,RM (1992))

Tetracyn State

Solid

Tetracyn LogP

-0.304

Tetracyn Dosage Forms

Tablets; Oral suspension; Capsules; Topical solution; Ophthalmic suspension; IV injection; IM injection; Ointment

Tetracyn Indication

Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, and tick fevers; upper respiratory infections; pneumonia; gonorrhea; amoebic infections; and urinary tract infections. It is also used to help treat severe acne and to treat trachoma (a chronic eye infection) and conjunctivitis (pinkeye). Tetracycline is often an alternative drug for people who are allergic to penicillin.

Tetracyn Pharmacology

Tetracycline is a short-acting antibiotic semisynthetically produced from chlortetracycline, which is derived from Streptomyces aureofaciens. Tetracycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. This binding is reversible in nature.

Tetracyn Absorption

Bioavailability is less than 40% when administered via intramuscular injection, 100% intravenously, and 60-80% orally (fasting adults). Food and/or milk reduce GI absorption of oral preparations of tetracycline by 50% or more.

Tetracyn side effects and Toxicity

LD50=808mg/kg (orally in mice)

Tetracyn Patient Information

Tetracyn Organisms Affected

Enteric bacteria and other eubacteria