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TAC Brand names, TAC Analogs

TAC Brand Names Mixture

  • No information avaliable

TAC Chemical_Formula


TAC RX_link

No information avaliable

TAC fda sheet

TAC msds (material safety sheet)


TAC Synthesis Reference

No information avaliable

TAC Molecular Weight

380.657 g/mol

TAC Melting Point

No information avaliable

TAC H2O Solubility

No information avaliable

TAC State




TAC Dosage Forms

No information avaliable

TAC Indication

Used in the treatment of oedema (including that associated with heart failure) and hypertension.

TAC Pharmacology

Trichloromethiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Trichloromethiazide has also been found useful in edema due to various forms of renal dysfunction such as nephrotic syndrome, acute glomer-ulonephritis, and chronic renal failure. Trichloromethiazide is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension. Like other thiazides, Trichloromethiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.

TAC Absorption

No information avaliable

TAC side effects and Toxicity

Oral Rat LD50 = 5600 mg/kg, oral Mouse LD50 = 2600 mg/kg

TAC Patient Information

No information avaliable

TAC Organisms Affected

Humans and other mammals