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Solvocin Brand names, Solvocin Analogs

Solvocin Brand Names Mixture

  • Delta-Albaplex tablets (Novobiocin sodium + Prednisolone + Tetracycline hydrochloride)
  • Neo Chlor PWR (Neomycin sulfate + Tetracycline hydrochloride)
  • Neo-Chlor (Neomycin sulfate + Tetracycline hydrochloride)
  • Neotetramed PWR (Neomycin sulfate + Tetracycline hydrochloride)
  • P Onytricin P (Calcium D-pantothenate + Menadione sodium bisulfite + Nicotinamide + Tetracycline hydrochloride + Vitamin A + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin D3 + Vitamin E)

Solvocin Chemical_Formula

C22H24N2O8

Solvocin RX_link

http://www.rxlist.com/cgi/generic2/tetcycl2.htm

Solvocin fda sheet

Solvocin msds (material safety sheet)

Solvocin MSDS

Solvocin Synthesis Reference

J. H. Boothe et al., J. Am. Chem. Soc. 75, 4621 (1953)

Solvocin Molecular Weight

444.435 g/mol

Solvocin Melting Point

165oC

Solvocin H2O Solubility

231 mg/L at 25 oC (SRC PhysProp experimental -- YALKOWSKY,SH & DANNENFELSER,RM (1992))

Solvocin State

Solid

Solvocin LogP

-0.304

Solvocin Dosage Forms

Tablets; Oral suspension; Capsules; Topical solution; Ophthalmic suspension; IV injection; IM injection; Ointment

Solvocin Indication

Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, and tick fevers; upper respiratory infections; pneumonia; gonorrhea; amoebic infections; and urinary tract infections. It is also used to help treat severe acne and to treat trachoma (a chronic eye infection) and conjunctivitis (pinkeye). Tetracycline is often an alternative drug for people who are allergic to penicillin.

Solvocin Pharmacology

Tetracycline is a short-acting antibiotic semisynthetically produced from chlortetracycline, which is derived from Streptomyces aureofaciens. Tetracycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. This binding is reversible in nature.

Solvocin Absorption

Bioavailability is less than 40% when administered via intramuscular injection, 100% intravenously, and 60-80% orally (fasting adults). Food and/or milk reduce GI absorption of oral preparations of tetracycline by 50% or more.

Solvocin side effects and Toxicity

LD50=808mg/kg (orally in mice)

Solvocin Patient Information

Solvocin Organisms Affected

Enteric bacteria and other eubacteria