Sumycin Syrup
Brand names,
Sumycin Syrup
Analogs
Sumycin Syrup
Brand Names Mixture
- Delta-Albaplex tablets (Novobiocin sodium + Prednisolone + Tetracycline hydrochloride)
- Neo Chlor PWR (Neomycin sulfate + Tetracycline hydrochloride)
- Neo-Chlor (Neomycin sulfate + Tetracycline hydrochloride)
- Neotetramed PWR (Neomycin sulfate + Tetracycline hydrochloride)
- P Onytricin P (Calcium D-pantothenate + Menadione sodium bisulfite + Nicotinamide + Tetracycline hydrochloride + Vitamin A + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin D3 + Vitamin E)
Sumycin Syrup
Chemical_Formula
C22H24N2O8
Sumycin Syrup
RX_link
http://www.rxlist.com/cgi/generic2/tetcycl2.htm
Sumycin Syrup
fda sheet
Sumycin Syrup
msds (material safety sheet)
Sumycin Syrup
Synthesis Reference
J. H. Boothe et al., J. Am. Chem. Soc. 75, 4621 (1953)
Sumycin Syrup
Molecular Weight
444.435 g/mol
Sumycin Syrup
Melting Point
165oC
Sumycin Syrup
H2O Solubility
231 mg/L at 25 oC (SRC PhysProp experimental -- YALKOWSKY,SH & DANNENFELSER,RM (1992))
Sumycin Syrup
State
Solid
Sumycin Syrup
LogP
-0.304
Sumycin Syrup
Dosage Forms
Tablets; Oral suspension; Capsules; Topical solution; Ophthalmic suspension; IV injection; IM injection; Ointment
Sumycin Syrup
Indication
Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, and tick fevers; upper respiratory infections; pneumonia; gonorrhea; amoebic infections; and urinary tract infections. It is also used to help treat severe acne and to treat trachoma (a chronic eye infection) and conjunctivitis (pinkeye). Tetracycline is often an alternative drug for people who are allergic to penicillin.
Sumycin Syrup
Pharmacology
Tetracycline is a short-acting antibiotic semisynthetically produced from chlortetracycline, which is derived from Streptomyces aureofaciens. Tetracycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. This binding is reversible in nature.
Sumycin Syrup
Absorption
Bioavailability is less than 40% when administered via intramuscular injection, 100% intravenously, and 60-80% orally (fasting adults). Food and/or milk reduce GI absorption of oral preparations of tetracycline by 50% or more.
Sumycin Syrup
side effects and Toxicity
LD50=808mg/kg (orally in mice)
Sumycin Syrup
Patient Information
Sumycin Syrup
Organisms Affected
Enteric bacteria and other eubacteria