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Amycin Brand names, Amycin Analogs

Amycin Brand Names Mixture

  • Delta-Albaplex tablets (Novobiocin sodium + Prednisolone + Tetracycline hydrochloride)
  • Neo Chlor PWR (Neomycin sulfate + Tetracycline hydrochloride)
  • Neo-Chlor (Neomycin sulfate + Tetracycline hydrochloride)
  • Neotetramed PWR (Neomycin sulfate + Tetracycline hydrochloride)
  • P Onytricin P (Calcium D-pantothenate + Menadione sodium bisulfite + Nicotinamide + Tetracycline hydrochloride + Vitamin A + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin D3 + Vitamin E)

Amycin Chemical_Formula

C22H24N2O8

Amycin RX_link

http://www.rxlist.com/cgi/generic2/tetcycl2.htm

Amycin fda sheet

Amycin msds (material safety sheet)

Amycin MSDS

Amycin Synthesis Reference

J. H. Boothe et al., J. Am. Chem. Soc. 75, 4621 (1953)

Amycin Molecular Weight

444.435 g/mol

Amycin Melting Point

165oC

Amycin H2O Solubility

231 mg/L at 25 oC (SRC PhysProp experimental -- YALKOWSKY,SH & DANNENFELSER,RM (1992))

Amycin State

Solid

Amycin LogP

-0.304

Amycin Dosage Forms

Tablets; Oral suspension; Capsules; Topical solution; Ophthalmic suspension; IV injection; IM injection; Ointment

Amycin Indication

Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, and tick fevers; upper respiratory infections; pneumonia; gonorrhea; amoebic infections; and urinary tract infections. It is also used to help treat severe acne and to treat trachoma (a chronic eye infection) and conjunctivitis (pinkeye). Tetracycline is often an alternative drug for people who are allergic to penicillin.

Amycin Pharmacology

Tetracycline is a short-acting antibiotic semisynthetically produced from chlortetracycline, which is derived from Streptomyces aureofaciens. Tetracycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. This binding is reversible in nature.

Amycin Absorption

Bioavailability is less than 40% when administered via intramuscular injection, 100% intravenously, and 60-80% orally (fasting adults). Food and/or milk reduce GI absorption of oral preparations of tetracycline by 50% or more.

Amycin side effects and Toxicity

LD50=808mg/kg (orally in mice)

Amycin Patient Information

Amycin Organisms Affected

Enteric bacteria and other eubacteria